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Raynaud's phenomenon is a disorder that affects the blood vessels in the fingers, toes, ears and nose. This disorder is characterized by episodic attacks, called vasospastic attacks, that cause the blood vessels in the digits (fingers and toes) to constrict (narrow). Raynaud's phenomenon can occur on its own, or it can be secondary to another condition such as scleroderma or lupus. (Read about "Scleroderma" "Lupus")
The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) says although estimates vary, recent surveys show that Raynaud's phenomenon may affect 5 to 10 percent of the general population in the United States. Women are more likely than men to have the disorder. Raynaud's phenomenon appears to be more common in people who live in colder climates. However, people with the disorder who live in milder climates may have more attacks during periods of colder weather.
For most people, an attack is usually triggered by exposure to cold or emotional stress. (Read about "Stress") In general, attacks affect the fingers or toes but may affect the nose, lips or ear lobes. When a person is exposed to cold, the body's normal response is to slow the loss of heat and preserve its core temperature. To maintain this temperature, the blood vessels that control blood flow to the skin surface move blood from arteries near the surface to veins deeper in the body. For people who have Raynaud's phenomenon, this normal body response is intensified by the sudden spasmodic contractions of the small blood vessels (arterioles) that supply blood to the fingers and toes. The arteries of the fingers and toes may also collapse. As a result, the blood supply to the extremities is greatly decreased, causing a reaction that includes skin discoloration and other changes.
Once the attack begins, a person may experience three phases of skin color changes (white, blue and red) in the fingers or toes. The order of the changes of color is not the same for all people, according to NIAMS and not everyone has all three colors.
As the attack ends, throbbing and tingling may occur in the fingers and toes. An attack can last from less than a minute to several hours.
Doctors classify Raynaud's phenomenon as either the primary or the secondary form. In medical literature, "primary Raynaud's phenomenon" may also be called Raynaud's disease, idiopathic Raynaud's phenomenon or primary Raynaud's syndrome. The terms idiopathic and primary, both mean that the cause is unknown.
Secondary Raynaud's phenomenon - NIAMS says secondary Raynaud's phenomenon is less common than the primary form, but it is often a more complex and serious disorder. Secondary means that patients have an underlying disease or condition that causes Raynaud's phenomenon. Connective tissue diseases are the most common cause of secondary Raynaud's phenomenon. Some of these diseases reduce blood flow to the digits by causing blood vessel walls to thicken and the vessels to constrict too easily. Raynaud's phenomenon is seen in approximately 85 to 95 percent of patients with scleroderma and mixed connective tissue disease, and it is present in about one-third of patients with systemic lupus erythematosus. (Read about "Lupus") Raynaud's phenomenon also can occur in patients who have other connective tissue diseases, including Sjögren's Syndrome (Read about "Sjögren's Syndrome"), dermatomyositis and polymyositis. (Read about dermatomyositis and polymyositis under Inflammatory Myopathies in "Neuromuscular Diseases")
Possible causes of secondary Raynaud's phenomenon, other than connective tissue diseases, are carpal tunnel syndrome (Read about "Carpal Tunnel Syndrome") and obstructive arterial disease (Read about "Coronary Heart Disease" and "Peripheral Arterial Disease"). Some drugs, including beta-blockers (used to treat high blood pressure), ergotamine preparations (used for migraine headaches), certain agents used in cancer chemotherapy, and drugs that cause vasoconstriction (such as some over-the-counter cold medications and narcotics), are linked to Raynaud's phenomenon. (Read about "Hypertension: High Blood Pressure" "Migraine Headaches" "Cancer Treatments")
People in certain occupations may be more vulnerable to secondary Raynaud's phenomenon. Some workers in the plastics industry (who are exposed to vinyl chloride) develop a scleroderma-like illness, of which Raynaud's phenomenon can be a part. Workers who operate vibrating tools can develop a type of Raynaud's phenomenon called vibration-induced white finger.
People with secondary Raynaud's phenomenon often experience associated medical problems. The more serious problems are skin ulcers (sores) or gangrene (tissue death) in the fingers or toes. Painful ulcers and gangrene are fairly common and can be difficult to treat. In addition, a person may experience heartburn (Read about "Heartburn") or difficulty in swallowing. These two problems are caused by weakness in the muscle of the esophagus (the tube that takes food and liquids from the mouth to the stomach) that can occur in people with connective tissue diseases.
If a doctor suspects Raynaud's phenomenon, he or she will ask the patient for a detailed medical history. The doctor will then examine the patient to rule out other medical problems. The patient might have a vasospastic attack during the office visit, which makes it easier for the doctor to diagnose Raynaud's phenomenon. Most doctors find it fairly easy to diagnose Raynaud's phenomenon but more difficult to identify the form of the disorder, according to NIAMS.
The aims of treatment are to reduce the number and severity of attacks and to prevent tissue damage and loss in the fingers and toes. NIAMS says many doctors are conservative in treating patients with primary and secondary Raynaud's phenomenon; that is, they recommend non-drug treatments and self-help measures first. Doctors may prescribe medications for some patients, usually those with secondary Raynaud's phenomenon. In addition, patients are treated for any underlying disease or condition that causes secondary Raynaud's phenomenon.
NIAMS says there are things that you can do. Several non-drug treatments and self-help measures can decrease the severity of Raynaud's attacks and promote overall well-being.
People with secondary Raynaud's phenomenon are more likely than those with the primary form to be treated with medications, according to NIAMS. Many doctors believe that the most effective and safest drugs are calcium-channel blockers, which relax smooth muscle and dilate the small blood vessels. These drugs decrease the frequency and severity of attacks in about two-thirds of patients who have primary and secondary Raynaud's phenomenon. These drugs also can help heal skin ulcers on the fingers or toes.
Other patients have found relief with drugs called alpha blockers that counteract the actions of norepinephrine, a hormone that constricts blood vessels. Some doctors prescribe a nonspecific vasodilator (drug that relaxes blood vessels), such as nitroglycerine paste, which is applied to the fingers, to help heal skin ulcers. Patients should keep in mind that the treatment for Raynaud's phenomenon is not always successful. Often, patients with the secondary form will not respond as well to treatment as those with the primary form of the disorder.
Patients may find that one drug works better than another. Some people may experience side effects that require stopping the medication. For other people, a drug may become less effective over time. Women of childbearing age should know that the medications used to treat Raynaud's phenomenon may affect the growing fetus. Therefore, women who are pregnant or are trying to become pregnant should avoid taking these medications if possible, according to NIAMS. (Read about "Healthy Pregnancy")
All Concept Communications material is provided for information only and is neither advice nor a substitute for proper medical care. Consult a qualified healthcare professional who understands your particular history for individual concerns.
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